human papovavirus BK

natural history and pathogenesis in man
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Rodopi , Amsterdam
Papovavir
Statementdoor Jaap Goudsmit.
The Physical Object
Pagination107 p. :
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Open LibraryOL14276934M

Human Papovavirus, BK Strain: Biological Studies Including Antigenic Relationship to Simian Virus 40 Article (PDF Available) in Journal of Virology 12(3) October with Reads. Abstract. The human polyomaviruses BK (BKV) and JC (JCV) are ubiquitous in human populations and have a worldwide distribution.

(1) They are oncogenic in rodents and monkeys and transform cells in vitro to a neoplastic phenotype. For all these reasons, BKV and JCV have been considered possible candidates in the etiology of human by: The isolation of a new papovavirus Summary from the urine of a renal allograft recipient with ureteric obstruction is described.

Virus particles were observed in the cells lining the ureter by electron microscopy, and high, rising antibody titres to the virus were demonstrated in the patient's serum. This virus is not identical with any of the previously described members of the polyoma Cited by: Concurrently, another human papovavirus was isolated by Gardner and her colleagues 5 from the urine of a renal transplant recipient and also named after the initials of the patient, BK.

Although BK virus (BKV) is still not clearly identified with a specific disease, JC virus (JCV) is now recognized as the causative agent for PML and has been. Henriksen S, et al. Human BK polyomavirus plasmid pBKV () (Dunlop) contains mutations not found in the originally published sequences. Genome Announc.

3(2): e, PubMed: Seif I, et al. The Genome of human papovavirus BKV. CellPubMed: The BK and JC viruses belong to the human papovavirus family. Reactivation of virus can occur after transplantation and has been associated with hemorrhagic cystitis, progressive multifocal leukoencephalopathy, and interstitial nephritis.

Human papovavirus BK book in situ hybridization and PCR techniques can demonstrate papovavirus in body fluids and tissues. The presence of viral receptors for the human papovavirus BK on most human peripheral B lymphocytes and on few human peripheral T lymphocytes was demonstrated by a rosetting technique.

This is a preview of subscription content, log in to check access. The papovavirus family includes viruses which can infect animals and man. In addition to human papilloma virus, a number of other human papovaviruses similar to SV40, including the types JC and BK (see Chapter 33), have been isolated.

Papovaviruses show marked similarities, both in structure and genetic composition, and they most likely have a.

Of the several dozen members of the papovavirus family, only a handful are associated with human disease. These viruses are human papillomavirus human papovavirus BK book, and two members of the polyoma subgroup JC virus and BK virus.

In recent years, HPV, in particular, has become a major source of concern as it has been consistently linked to genital cancer. Read or download pdf books in English and in Hindi, published by Brahma Kumaris Godly Spiritual University, Om Shanti press. Authors: BK Jagdish bhai, BK Shivani, SpARC wing, BK Suraj bhai, and BK main aim of these books is to explain the Godly knowledge and revelations of murli to the general audience and new BKs.

Books on Self-realisation, on God, celibacy, eternal World Drama Missing: papovavirus. BK virus, unassociated with any recognizable disease but widely distributed in the human population, has been the subject of numerous serological and epidemiological investigations. Various immunological methods are available, the haemagglutination-inhibition test being most widely used.

Gel diffusion methods have had a limited application owing to their low degree of sensitivity but, although. The PA/PO/VA virus family members of human importance are the “pa,” or papilloma viruses (see Chapter 21), “po,” or polyomaviruses (JCV and BKV are the only established human representatives), and “va” (referring to the cytological vacuolization that occurs in epithelial cells infected with SV40, an endogenous virus of several subhuman primate species).

Immunoelectroosmophoresis for the human papovavirus BK. BK virus, a relative of JC virus, which is the etiologic agent of progressive multifocal leukoencephalopathy (PML), was first isolated in from a urine sample obtained from a renal transplant recipient [].The name of the virus refers to the first patient's initials, which is also true of JC virus [].This member of the polyoma subgroup of papovaviruses, which includes BK virus, JC virus.

Gardner S.D., Field A.M., Coleman D.V., Hulme B. ‘New human papovavirus (BK) isolated from urine after renal transplantation. Lancet ’; 1() The DNA of the BK virus (BKV) human papovavirus was found to be heterogeneous, consisting of at least four discrete species of DNA.

Only the largest of these four species, BKV DNA (i). The BK virus was first isolated in from the urine of a renal transplant patient, initials B.K. New human papovavirus (B.K.) isolated from urine after renal transplantation. Gardner SD, Field AM, Coleman DV, Hulme B.

Lancet. Jun 19;1() Some of the properties of a new human papovavirus, BK, have been examined. Host range studies of BK virus (BKV) showed human cells to be more sensitive to infection than monkey cells; human fetal brain cells appear to be highly sensitive to BKV, with the production of extensive cytopathology characterized by cytoplasmic vacuolization.

Sera and cerebrospinal fluids (CSF) from 10 patients with subacute sclerosing panencephalitis (SSPE) were tested for antibodies to the BK virus, a new tentative member of the papovavirus group, in an effort to determine any relationships between BK virus and SSPE and the papova-like virus seen in glial cells of SSPE patients.

Serum specimens from a group of 50 multiple sclerosis (MS) patients. Abstract. BK virus (BKV), JC virus (JCV) and Simian Virus 40 (SV40) are polyomaviruses, highly homologous at the DNA and protein levels. While the human polyomaviruses BKV and JCV are ubiquitous in humans, SV40 is a simian virus which was introduced in the human population, between andby contaminated poliovaccines produced in SVinfected monkey cells.

The data presented here clearly indicate that BKvirus, a human papovavirus, is able to cause malignant transforma-tion of BHK21 clone 13 cells. Malignant transformation of BHK21clone 13 cells byBKvirus invitro wascomparedwith the transformation of BHK21 clone 13 cells by a known oncogenic papovavirus, polyoma.

Description human papovavirus BK EPUB

With both viruses, trans. In one study, BK viruria was present in % of normal subjects, % with renal disease (not translplant recipients), and % with renal disease and steroid tx.

[1] [1] Kaneko T et al. Prevalence of human polyoma virus (BK virus and JC virus) infection in patients with chronic renal disease. Clin. Exp. Nephrol. Jun;9(2)\. The DNA of the BK virus (BKV) human papovavirus was found to be heterogeneous, consisting of at least four discrete species of DNA.

Only the largest of these four species, BKV DNA (i), which has a. Abstract Some of the properties of a new human papovavirus, BK, have been examined. Host range studies of BK virus (BKV) showed human cells to be more sensitive to infection than monkey cells; human fetal brain cells appear to be highly sensitive to BKV, with the production of extensive cytopathology characterized by cytoplasmic vacuolization.

The DNA of the BK virus human papovavirus was found to be heterogeneous, consisting of at least four discrete species of DNA.

Only the largest of these four species, BKV DNA (i), which has a molecular weight calculated to be 96% that of simian virus 40 DNA, was neous preparations of BKV DNA were obtained, however, from virions purified after low multiplicity infections of.

Representative Papovaviruses: Genus Papillomavirus: Human papillomaviruses (HPV ) Shope papilloma virus of rabbits Genus Polyomavirus; Polyoma virus of mice Simian virus 40 (SV40) JC and BK viruses These two genera differ in several aspects: 1) capsid size (Polyoma = 40 nm, Papilloma = 55 nm) 2) length of genome (Polyoma = 5 kb, Papilloma.

Search the world's most comprehensive index of full-text books. My libraryMissing: papovavirus. BK virus (BKV) was originally detected in the urine of a renal allograft recipient in whom ureteric stenosis developed and was named based on the initials of the patient (B.K.).

1 The virus is ubiquitous in human populations worldwide. 2 Infection typically occurs in childhood, with a seroprevalence up to 90% in adults.

3 BKV is a urotheliotropic virus that becomes latent in the urinary tract.

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Abstract BK virus, a widespread human papovavirus, is shown to cause malignant transformation of BHK 21 clone 13 cells.

The transformed cells grow as tumors upon inoculation in adult hamsters. The question of the possible role of this virus in human neoplasia is raised. Major EO, Di Mayorca G.

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Malignant transformation of BHK21 clone 13 cells by BK virus--a human papovavirus. Proc Natl Acad Sci U S A. Nov; 70 (11)– [PMC free article] Mullarkey MF, Hruska JF, Takemoto KK. Comparison of two human papovaviruses with simian virus 40 by structural protein and antigenic analysis.

J Virol. The DNA of three cloned lines of hamster kidney cells transformed by human papovavirus BK DNA was examined by reassociation kinetics for viral sequences and found to contain to equivalents of viral DNA per diploid genome.

In the one line examined with the four R-HindIII fragments of the human papovavirus BK genome, the entire viral.Comparison of JC and BK human papovaviruses with simian virus DNA homology studies Article (PDF Available) in Journal of Virology 19(2) September with 36 Reads How we measure.Abstract.

Complementation tests between BK human papovavirus and SV40 temperature-sensitive mutants tsA58 and tsB11 were performed. Under the reported experimental conditions, BKV complemented the “early” mutant tsA58 but failed to complement the “late” mutant tsB